Where the physiology
meets the clock
We are a basic science and translational research lab dedicated to exploring the circadian clock’s role in skin biology. Our studies involve different aspects of skin biology. We consider the variable “time” into account in our experiments and utilize several experimental models and omics methods to answer our questions.
The physiological regulation of our bodily functions is dynamic rather than static; it operates in cycles. Most of these fluctuations occur over a 24-hour period, known as circadian rhythms. Our aim is to understand these circadian oscillations and their effects on skin biology, yielding both fundamental and clinical insights.
Our biological processes are not static; they display moments of high and low activity. Studying the effects of time on biological systems falls within the chronobiological field. We investigate how circadian rhythms regulate skin processes, such as barrier function, DNA repair, and proliferation. Our goal is to understand how the cutaneous clock is synchronized with the external and internal environments.
The skin is comprised of several different cells which are connected to each other and comprise a dynamic interactome. This intratissue connection is critical for healthy skin. We aim to understand how this communication between skin cells happens in physiological and pathological conditions.
Our goal is to map the molecular alterations in various skin diseases to improve their diagnosis and treatment.
Associate Senior Lecturer
(Assistant Professor)
University of Gothenburg
Leonardo de Assis is a pharmacist (Brazil) and holds a PhD in physiology (Brazil). In his PhD and first postdoc, Leonardo investigated the function of the light-sensitive system of the skin. In a second postdoc in Germany, Leonardo specialized in circadian biology and metabolism where he delved into the temporal regulation of thyroid hormones. Leonardo de Assis is an Assistant Professor (Senior Associate Lecturer) at the University of Gothenburg, Sweden, and a researcher at The Wallenberg Centre for Molecular and Translational Medicine. He leads the Circadian Skin Biology Lab (CSBL), whose research focuses on how the circadian clock influences skin biology and its potential for treating skin diseases. Leonardo’s research interests span metabolism, skin biology, circadian rhythms, bioinformatics, and photobiology.
Publications
Google Scholar | Research Gate | Web of Science
